The Challenge: The potential drug NELL-1 both builds bone and slows breakdown, but its administration method was prohibitive.Most osteoporosis drugs work to slow bone breakdown, not form new bone, but studies in mice have shown that NELL-1 does both. However, use of NELL-1 was possible only via injection into the mouse’s bone during surgery. To make NELL-1 more useful for human patients, it needed to be modified for systemic administration.
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