Many crystallization experiments in space over the past three decades demonstrate the value of the ISS for improving molecular crystal growth. In 2014, the ISS National Laboratory began sponsoring its own series of crystal growth investigations, and many have yielded high-quality crystals for analysis. Most projects focus on structural determination for drug design, but others aim to improve drug formulation, manufacturing, and storage. Examples of repeat customers of the ISS National Laboratory in the area of protein crystal growth include Merck & Co., Eli Lilly & Co., The Michael J. Fox Foundation, and Oak Ridge National Lab. Some companies are additionally crystallizing inorganic compounds, toward advancements in materials science. Moreover, multiple workshops held by the ISS National Laboratory over the past five years have produced actionable findings to help improve user success, including guidelines for informed molecule selection.